A Self-Killing Rabies Virus That Leaves a Trace on the DNA
Publication information:
Menegas, W.; Uchida, N.; Watabe-Uchida, M.
A Self-Killing Rabies Virus That Leaves a Trace on the DNA. Trends Neurosci. 2017, 40 (10), 589-591.
Abstract
Although modified rabies viruses have emerged as a powerful tool for tracing the inputs to genetically defined populations of neurons, the toxicity of the virus has limited its utility. A recent study employed a self-inactivating rabies (SiR) virus that enables recording or manipulation of targeted neurons for months.